RPSA/Laminin Receptor Antikörper

Produktnummer ABIN1713335

This anti-RPSA/Laminin Receptor antibody (ABIN1713335) is a Mouse Monoclonal antibody detecting RPSA/Laminin Receptor in WB, IHC (p), IF (p). Suitable for Human, Rat.

Kurzübersicht für RPSA/Laminin Receptor Antikörper (ABIN1713335)

Target: RPSA/Laminin Receptor (RPSA) (Ribosomal Protein SA (RPSA))

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RPSA/Laminin Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Klon: 5D4

Produktdetails anti-RPSA/Laminin Receptor Antikörper

Kreuzreaktivität: Human, Ratte

Aufreinigung: Purified by Protein G.

Immunogen: KLH conjugated synthetic peptide derived from middle of human LAMR1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-RPSA/Laminin Receptor Antikörper (ABIN1713335)

Wang, Yu, Guan, Liu, Qiao: "67-kDa Laminin receptor contributes to hypoxia-induced migration and invasion of trophoblast-like cells by mediating matrix metalloproteinase-9." in: Clinical and experimental pharmacology & physiology, Vol. 42, Issue 5, pp. 549-58, (2015) (PubMed).

Details zu RPSA/Laminin Receptor

Target: RPSA/Laminin Receptor (RPSA) (Ribosomal Protein SA (RPSA))

Andere Bezeichnung: LAMR1

Hintergrund:

Synonyms: 37LRP, P37- kDa laminin receptor precursor, MGr1-Ag, laminin receptor 1, 67kD, ribosomal protein SA, 34/67 kDa laminin receptor, 40S ribosomal protein SA, 67LR, Colon carcinoma laminin-binding protein, LAMBR, Laminin Receptor 1, LAMR 1, LAMR1, LRP, Multidrug resistance-associated protein MGr1-Ag, NEM/1CHD4, p40, Ribosomal Protein SA, RPSA, 67kD laminin receptor.

Background: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gen-ID: 3921

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly