SKAP1 Antikörper (AA 101-200) (HRP)

Produktnummer ABIN1712604

Der HRP-konjugierte Kaninchen Polyklonal anti-SKAP1 Antikörper (ABIN1712604) detektiert spezifisch SKAP1 in IHC (p) und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für SKAP1 Antikörper (AA 101-200) (HRP) (ABIN1712604)

Target: SKAP1 (Src Kinase Associated phosphoprotein 1 (SKAP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SKAP1 Antikörper ist konjugiert mit HRP

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-SKAP1 Antikörper (HRP)

Bindungsspezifität: AA 101-200

Verwendungszweck: SKAP55 Polyclonal Antibody, HRP Conjugated

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Dog,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SKAP55

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu SKAP1

Target: SKAP1 (Src Kinase Associated phosphoprotein 1 (SKAP1))

Andere Bezeichnung: SKAP55

Hintergrund:

Synonyms: pp55, SCAP 1, SCAP1, SKAP 1, SKAP 55, SKAP-55, Skap1, SKAP1_HUMAN, SKAP55 adaptor protein, SRC family associated phosphoprotein 1, Src family-associated phosphoprotein 1, Src kinase associated phosphoprotein 1, SRC kinase associated phosphoprotein 55 kD, Src kinase associated phosphoprotein of 55 kDa, Src kinase-associated phosphoprotein 1, Src kinase-associated phosphoprotein of 55 kDa.

Background: Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn. SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells. SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines. SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain. SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation. The human SKAP55 gene maps to chromosome 17q21.32 and encodes a 359 amino acid protein.