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Inversin Antikörper (AA 31-130) (HRP)

Der Kaninchen Polyklonal Anti-Inversin-Antikörper wurde für WB, ELISA, IHC (fro) und IHC (p) validiert. Er ist geeignet, Inversin in Proben von Human und Maus zu detektieren.
Produktnummer ABIN1711901

Kurzübersicht für Inversin Antikörper (AA 31-130) (HRP) (ABIN1711901)

Target

Alle Inversin (INVS) Antikörper anzeigen
Inversin (INVS)

Reaktivität

  • 28
  • 16
  • 2
Human, Maus

Wirt

  • 29
  • 1
Kaninchen

Klonalität

  • 30
Polyklonal

Konjugat

  • 13
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Inversin Antikörper ist konjugiert mit HRP

Applikation

  • 26
  • 13
  • 13
  • 10
  • 10
  • 4
  • 3
  • 3
  • 2
  • 2
Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    • 14
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 31-130

    Kreuzreaktivität

    Human, Maus

    Homologie

    Rat,Cow,Sheep,Chimpanzee

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human Inversin

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    Inversin (INVS)

    Andere Bezeichnung

    Inversin

    Hintergrund

    Synonyms: INV, Inversion of embryo turning homolog, inversion of embryonic turning, INVS, Nephrocystin 2, Nephrocystin-2, Nephrocystin2, nephronophthisis 2 infantile, NPH2, NPHP2, INVS_HUMAN.

    Background: Nephrocystin-2 is a 1,065 amino acid protein that exists as three alternatively spliced isoforms and is essential for establishment of the left-right axis and normal renal development. Localizing to the cytoplasm, cytoskeleton, membrane and nucleus, nephrocystin-2 is expressed during presomite-stage embryos and persists in adulthood, with high levels of expression in liver and kidney. Mice expressing nephrocystin-2 mutations are primarily generated by random insertional mutagenesis and result in the reversal of left/right polarity and cyst formation in the kidneys. Furthermore, altered nephrocystin-2 function reverses nodal and lefty expression, indicating that nephrocystin-2 signaling occurs upstream of these proteins involved in the development of asymmetry.

    Gen-ID

    27130
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