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GUCA1C Antikörper (AA 141-209) (HRP)

GUCA1C Reaktivität: Human WB, ELISA, IHC (fro), IHC (p) Wirt: Kaninchen Polyclonal HRP
Produktnummer ABIN1711020
  • Target Alle GUCA1C Antikörper anzeigen
    GUCA1C (Guanylate Cyclase Activator 1C (GUCA1C))
    Bindungsspezifität
    • 14
    • 14
    • 7
    • 3
    • 1
    AA 141-209
    Reaktivität
    Human
    Wirt
    • 30
    • 2
    Kaninchen
    Klonalität
    • 31
    • 1
    Polyklonal
    Konjugat
    • 9
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GUCA1C Antikörper ist konjugiert mit HRP
    Applikation
    • 32
    • 15
    • 13
    • 13
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Kreuzreaktivität
    Human
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GCAP3
    Isotyp
    IgG
    Top Product
    Discover our top product GUCA1C Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handhabung
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    GUCA1C (Guanylate Cyclase Activator 1C (GUCA1C))
    Andere Bezeichnung
    GCAP3 (GUCA1C Produkte)
    Synonyme
    gcap3 antikoerper, GCAP3 antikoerper, guanylate cyclase activator 1C antikoerper, guca1c antikoerper, GUCA1C antikoerper
    Hintergrund

    Synonyms: GCAP 3, Guanylate cyclase activating photoreceptor 3, Guanylate cyclase activator 1C, Guanylyl cyclase activating protein 3, Guanylyl cyclase-activating protein 3, GUC1C_HUMAN, GUCA1C.

    Background: The intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating proteins (GCAP). GCAPs are calcium-binding proteins belonging to the calmodulin superfamily and are specifically expressed in retina. GCAP3 (Guanylyl cyclase-activating protein 3), also known as GUCA1C (Guanylate cyclase activator 1C), is a 209 amino acid EF-hand calcium binding protein that is activated by the decrease in calcium from the absorption of light by rhodopsin. Activation of GCAP3 leads to stimulation of guanylate cyclase 1 and 2 (GC1 and GC2), which increases cGMP concentration. Calcium sensitive regulation of GC is essential in recovery of the rod receptor dark state following light exposure. There are two isoforms of GCAP3 that are produced as a result of alternative splicing events.

    Gen-ID
    9626
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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