GUCA1C Antikörper (C-Term)

Produktnummer ABIN1881400

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch GUCA1C in WB. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 3+ Publikationen zitiert.

Kurzübersicht für GUCA1C Antikörper (C-Term) (ABIN1881400)

Target: GUCA1C (Guanylate Cyclase Activator 1C (GUCA1C))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GUCA1C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB42656

Produktdetails anti-GUCA1C Antikörper

Bindungsspezifität: AA 171-199, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GUCA1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-199 amino acids from the C-terminal region of human GUCA1C.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-GUCA1C Antikörper (ABIN1881400)

Stephen, Palczewski, Sousa: "The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies." in: Journal of molecular biology, Vol. 359, Issue 2, pp. 266-75, (2006) (PubMed).

Imanishi, Li, Sokal, Sowa, Lichtarge, Wensel, Saperstein, Baehr, Palczewski: "Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man." in: The European journal of neuroscience, Vol. 15, Issue 1, pp. 63-78, (2002) (PubMed).

Haeseleer, Sokal, Li, Pettenati, Rao, Bronson, Wechter, Baehr, Palczewski: "Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily." in: The Journal of biological chemistry, Vol. 274, Issue 10, pp. 6526-35, (1999) (PubMed).

Details zu GUCA1C

Target: GUCA1C (Guanylate Cyclase Activator 1C (GUCA1C))

Andere Bezeichnung: GUCA1C

Hintergrund: GUCA1C stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.

Molekulargewicht: 23822

NCBI Accession: NP_005450

UniProt: O95843

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction