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GUCA1C Antikörper (AA 141-209) (FITC)

This anti-GUCA1C antibody (ABIN1709207) is a Rabbit Polyclonal antibody detecting GUCA1C in WB, IF (cc), IF (p). Suitable for Human.
Produktnummer ABIN1709207

Quick Overview for GUCA1C Antikörper (AA 141-209) (FITC) (ABIN1709207)

Target

Alle GUCA1C Antikörper anzeigen
GUCA1C (Guanylate Cyclase Activator 1C (GUCA1C))

Reaktivität

Human

Wirt

  • 25
  • 2
Kaninchen

Klonalität

  • 26
  • 1
Polyklonal

Konjugat

  • 9
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser GUCA1C Antikörper ist konjugiert mit FITC

Applikation

  • 27
  • 12
  • 12
  • 11
  • 3
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 9
    • 3
    • 2
    • 1
    AA 141-209

    Kreuzreaktivität

    Human

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human GCAP3

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    GUCA1C (Guanylate Cyclase Activator 1C (GUCA1C))

    Andere Bezeichnung

    GCAP3

    Hintergrund

    Synonyms: GCAP 3, Guanylate cyclase activating photoreceptor 3, Guanylate cyclase activator 1C, Guanylyl cyclase activating protein 3, Guanylyl cyclase-activating protein 3, GUC1C_HUMAN, GUCA1C.

    Background: The intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating proteins (GCAP). GCAPs are calcium-binding proteins belonging to the calmodulin superfamily and are specifically expressed in retina. GCAP3 (Guanylyl cyclase-activating protein 3), also known as GUCA1C (Guanylate cyclase activator 1C), is a 209 amino acid EF-hand calcium binding protein that is activated by the decrease in calcium from the absorption of light by rhodopsin. Activation of GCAP3 leads to stimulation of guanylate cyclase 1 and 2 (GC1 and GC2), which increases cGMP concentration. Calcium sensitive regulation of GC is essential in recovery of the rod receptor dark state following light exposure. There are two isoforms of GCAP3 that are produced as a result of alternative splicing events.

    Gen-ID

    9626

    Pathways

    Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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