TMC8 Antikörper (AA 301-400) (Cy7)

Produktnummer ABIN1708252

Dieses Rabbit Polyclonal-Antikörper erkennt spezifisch TMC8 in WB, IF (cc), IF (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TMC8 Antikörper (AA 301-400) (Cy7) (ABIN1708252)

Target: TMC8 (Transmembrane Channel-Like 8 (TMC8))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TMC8 Antikörper ist konjugiert mit Cy7

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-TMC8 Antikörper (Cy7)

Bindungsspezifität: AA 301-400

Homologie: Human,Mouse,Rat,Cow,Sheep,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EVER2/TMC8

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu TMC8

Target: TMC8 (Transmembrane Channel-Like 8 (TMC8))

Andere Bezeichnung: EVER2/TMC8

Hintergrund:

Synonyms: epidermodysplasia verrucormis 2, Epidermodysplasia verrucormis protein 2, EV2, EVIN2, FLJ40668, FLJ43684, MGC102701, MGC40121, TMC8, Transmembrane channel like protein 8, TMC8_HUMAN.

Background: Transmembrane channel-like protein 8 (TMC8), also known as Epidermodysplasia verruciformis protein 2 (EVER2), is a 726 amino acid member of the TMC family of proteins. Localized to the endoplasmic reticulum membrane, TMC8 is thought to form a transmembrane channel-like protein with eight predicted transmembrane domains and three leucine zipper motifs. Mutations in the genes encoding TMC8 and TMC6, another member of the TMC family, have been shown to cause epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. Infection by HPVs lead to persistent wart-like or macular lesions. TMC8 is expressed in placenta, prostate and testis, and three named isoforms exist as a result of alternative splicing events.

Gen-ID: 147138