tRNA Aspartic Acid Methyltransferase 1 (TRDMT1) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1705119
Antigen
  • MGC89267
  • DMNT2
  • DNMT2
  • MHSAIIP
  • PUMET
  • RNMT1
  • Dnmt2
  • Rnmt2
  • dnmt2
  • tRNA aspartic acid methyltransferase 1
  • tRNA aspartic acid methyltransferase 1 L homeolog
  • trdmt1
  • TRDMT1
  • Trdmt1
  • trdmt1.L
Reaktivität
Human, Maus, Ratte (Rattus)
124
69
23
2
2
2
2
1
1
1
Wirt
Kaninchen
121
15
Klonalität
Polyklonal
Konjugat
Cy5
10
8
7
6
6
6
3
3
3
3
3
2
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
99
61
56
15
12
12
10
8
2
Optionen
Immunogen KLH conjugated synthetic peptide derived from human Dnmt2
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Dnmt2 (TRDMT1 Antibody Abstract)
Hintergrund

Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.

Synonyms: dDNMT, D mMT 2, D mMT2, DNA cytosine 5 methyltransferase 2, DNA cytosine 5 methyltransferase like protein 2, DNA cytosine-5-methyltransferase-like protein 2, DNA 5 cytosine methyltransferase, DNA methyltransferase 2, DNA methyltransferase homolog HsaIIP, DNA MTase homolog HsaIIP, Dnmt 2, Dnmt2, M.HsaIIP, MHsaIIP, nmt 2, nmt2, OTTHUMP00000045198, PuMet, RNMT 1, RNMT1, TRDMT 1, TRDMT_HUMAN, TRDMT1, tRNA cytosine 5 methyltransferase, tRNA cytosine38-C5-methyltransferase, tRNA aspartic acid methyltransferase 1, tRNA aspartic acid methyltransferase 1 variant 1, tRNA aspartic acid methyltransferase 1 variant 2, tRNA aspartic acid methyltransferase 1 variant 3, tRNA aspartic acid methyltransferase 1 variant 4, tRNA aspartic acid methyltransferase 1 variant 5, tRNA aspartic acid methyltransferase 1 variant 8.

Gen-ID 1787
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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