KIT Antikörper (Mast/stem Cell Growth Factor Receptor) (pTyr730) (Cy5)

Details for Product anti-KIT Antibody No. ABIN1705025
Antigen
  • C-Kit
  • CD117
  • PBT
  • SCFR
  • Bs
  • Fdc
  • Gsfsco1
  • Gsfsco5
  • Gsfsow3
  • SCO1
  • SCO5
  • SOW3
  • Ssm
  • Tr-kit
  • W
  • c-KIT
  • c-kit
  • MGF
  • KIT
  • C-KIT
  • kit
  • receptor
  • sparse
  • Xkl-1
  • kit-a
  • kit-b
  • kl1-A
  • krk1
  • pbt
  • scfr
  • KIT proto-oncogene receptor tyrosine kinase
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a
  • KIT proto-oncogene receptor tyrosine kinase S homeolog
  • KIT
  • Kit
  • kita
  • kit
  • kit.S
Epitop
pTyr730
67
66
65
60
53
47
33
32
31
31
25
24
21
21
17
17
17
17
17
17
17
16
16
16
16
16
16
16
16
16
16
15
15
15
15
15
12
10
10
9
9
9
9
9
9
9
8
8
8
8
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
5
5
5
4
4
4
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
1266
449
171
43
43
36
24
19
14
5
4
3
3
2
2
Wirt
Kaninchen
998
357
146
8
2
2
Klonalität
Polyklonal
Konjugat
Dieser KIT Antikörper ist konjugiert mit Cy5
141
129
125
106
85
75
19
17
15
14
14
14
8
8
8
8
8
8
6
5
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
681
612
418
327
207
146
109
104
68
60
51
30
18
13
10
10
10
3
2
2
2
2
1
1
Optionen
Immunogen KLH conjugated synthetic phosphopeptide derived from human c-Kit around the phosphorylation site of Tyr730
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere KIT products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung C-Kit (KIT Antibody Abstract)
Hintergrund

c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

Synonyms: c-Kit phospho Y730, c-Kit phospho Tyr730, p-c-Kit Tyr 730, C Kit, c-Kit, CD 117, CD117, CD117 antigen, KIT, KIT_HUMAN, Mast/stem cell growth factor receptor, Mast/stem cell growth factor receptor Kit, p145 c-kit, PBT, Piebald trait protein, Proto oncogene c Kit, Proto oncogene tyrosine protein kinase Kit, Proto-oncogene c-Kit, SCF Receptor, SCFR, soluble KIT variant 1, Stem cell factor receptor, tyrosine protein kinase Kit, Tyrosine-protein kinase Kit, v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog, v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog.
Gen-ID 3815
Pathways RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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