Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704902
Antigen
  • zgc:110190
  • zgc:92742
  • NR1H4
  • BAR
  • FXR
  • HRR-1
  • HRR1
  • RIP14
  • AI957360
  • Fxr
  • Rxrip14
  • nuclear receptor subfamily 1, group H, member 5 S homeolog
  • nuclear receptor subfamily 1, group H, member 4
  • nuclear receptor subfamily 1 group H member 4
  • nr1h5.S
  • nr1h4
  • NR1H4
  • Nr1h4
Reaktivität
Human
110
23
21
9
6
5
5
4
4
4
1
1
Wirt
Kaninchen
92
15
7
Klonalität
Polyklonal
Konjugat
Cy5
10
7
7
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
84
58
12
9
4
4
2
2
1
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human Bile Acid Receptor NR1H4
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Fxr/Bile Acid Receptor Nr1h4 (NR1H4 Antibody Abstract)
Hintergrund

The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, and several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed â€orphan receptors†because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.

Subcellular location: Nucleus

Synonyms: BAR, FXR, HRR1, HRR-1, PFIC5, RIP14, Bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14, NR1H4

Gen-ID 9971
UniProt Q96RI1
Pathways Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Carbohydrate Metabolic Process
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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