Protein Aurora Borealis Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704790
Antigen
  • CG6897
  • Dmel\\CG6897
  • zgc:101616
  • C13orf34
  • 6720463M24Rik
  • AI317232
  • RGD1309522
  • c13orf34
  • C12H13orf34
  • aurora borealis
  • bora, aurora kinase A activator
  • protein aurora borealis
  • bora, aurora kinase A activator S homeolog
  • bora
  • Tsp_06066
  • Bora
  • BORA
  • bora.S
Reaktivität
Human, Maus, Ratte (Rattus)
63
37
36
Wirt
Kaninchen
61
2
Klonalität
Polyklonal
Konjugat
Cy5
4
3
3
3
3
3
2
2
2
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
33
23
17
12
8
5
3
2
2
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human BORA
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Bora
Hintergrund

Aurora related kinase-1 (ARK-1) is a centrosome-associated serine/threonine kinase that regulates centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. Bora (protein aurora borealis) is a 559 amino acid protein that activates ARK-1. Bora is localized to the nucleus until mitosis is initiated, when it then translocates to the cytoplasm. This translocation is dependent on activated Cdc2, which releases Bora to bind and activate ARK-1 in the cytoplasm. Plk (polo-like kinase) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation on its N-terminus by ARK-1. It is through this mechanism that Bora and ARK-1 control cellular mitotic entry. Downregulation of the gene encoding Bora results in multipolar spindles in mitosis, a phenomenon that is also observed when ARK-1 function is blocked.

Synonyms: Aurora borealis, bora, BORA_HUMAN, C13orf34, Chromosome 13 open reading frame 34, FLJ22624, HsBora, Protein aurora borealis, RP11-342J4.2.

Gen-ID 79866
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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