AlkB, Alkylation Repair Homolog 1 (E. Coli) (ALKBH) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704770
Antigen
  • Alkbh
  • ABH
  • ABH1
  • ALKBH
  • alkB
  • hABH
  • 2700073G19Rik
  • Abh
  • alkB homolog 1, histone H2A dioxygenase
  • Alkbh1
  • ALKBH1
Reaktivität
Human, Maus, Ratte (Rattus)
75
35
22
2
1
1
1
1
1
Wirt
Kaninchen
69
6
Klonalität
Polyklonal
Konjugat
Cy5
3
3
3
3
3
3
2
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
44
16
16
12
9
6
4
Optionen
Immunogen KLH conjugated synthetic peptide derived from human ABH1/ALKB
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Abh1/Alkb (ALKBH Antibody Abstract)
Hintergrund

ALKB protects DNA and RNA against damage from methylating compounds from the environment by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzymes act by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate, and molecular oxygen as the oxidizing agent. Deficiencies in DNA and RNA repair in mammals are associated with cancer, neurological disease and developmental defects. ALKB plays a role in resistance to anti-cancer drugs which attempt to damage tumor DNA. Escherichia coli ALKB protein belongs to the superfamily of 2-oxoglutarate- and iron(II)-dependent oxygenases.

Synonyms: ABH, ABH1, alkB, AlkB, alkylation repair homolog 1 E. coli, ALKB1_HUMAN, ALKBH, ALKBH1, Alkylated DNA repair protein alkB homolog 1, Alkylation repair homolog 1, Alkylation repair, alkB homolog, Alpha-ketoglutarate-dependent dioxygenase ABH1, DNA lyase ABH1, hABH.

Gen-ID 8846
Pathways DNA Reparatur
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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