SIX Homeobox 2 (SIX2) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704693
Antigen
  • six2-A
  • zgc:195089
  • zgc:195096
  • SIX homeobox 2
  • sine oculis-related homeobox 2
  • SIX homeobox 2 S homeolog
  • SIX homeobox 2b
  • SIX2
  • Six2
  • six2.S
  • six2b
Reaktivität
Human, Maus, Ratte (Rattus)
56
32
31
2
2
2
2
2
2
2
1
1
1
1
Wirt
Kaninchen
52
5
Klonalität
Polyklonal
Konjugat
Cy5
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
39
28
12
7
4
3
2
2
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human SIX2
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Six2 (SIX2 Antibody Abstract)
Hintergrund

The Six proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. Six2, Six4 (AREC3) and Six5 bind to the same DNA sequence, indicating that they may regulate the same target genes. Six1 and Six4 are both capable of transactivating MEF3 site containing reporter genes, such as myogenin. It has been demonstrated that alterations to homeobox-containing genes may result in cancer. Six1 expression has been shown to be absent or low in normal adult tissues, although it is expressed in several tumor types, including breast carcinoma. Six1 overexpression has been shown to abrogate the G2 cell cycle checkpoint. Six2 is highly expressed in fetal tissues but expression is limited in adult tissues.

Synonyms: Homeobox protein SIX2, OTTHUMP00000201649, Sine oculis homeobox Drosophila homolog 2, Sine oculis homeobox homolog 2, Sine oculis homeobox homolog 2 Drosophila, SIX homeobox 2, Six2, SIX2_HUMAN.

Gen-ID 10736
Pathways Protein targeting to Nucleus
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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