SIX2 Antikörper

Produktnummer ABIN7119117

Produktdetails anti-SIX2 Antikörper

Target: SIX2 (SIX Homeobox 2 (SIX2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIX2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: SIX homeobox 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:1000, IP: 1:500-1:1000, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu SIX2

Target: SIX2 (SIX Homeobox 2 (SIX2))

Andere Bezeichnung: SIX2 (SIX2 Produkte)

Synonyme: six2-A antikoerper, zgc:195089 antikoerper, zgc:195096 antikoerper, six2.1 antikoerper, wu:fj04e08 antikoerper, zgc:91945 antikoerper, SIX homeobox 2 antikoerper, sine oculis-related homeobox 2 antikoerper, SIX homeobox 2 S homeolog antikoerper, SIX homeobox 2b antikoerper, SIX homeobox 2a antikoerper, SIX2 antikoerper, Six2 antikoerper, six2.S antikoerper, six2b antikoerper, six2a antikoerper

Hintergrund: Synonyms:Homeobox protein SIX2, Sine oculis homeobox homolog 2, SIX homeobox 2, SIX2 Background:Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. Also may be involved in limb tendon and ligament development(By similarity). Plays a role in cell proliferation and migration.

Molekulargewicht: 35 kDa

Gen-ID: 10736

UniProt: Q9NPC8

Pathways: Protein targeting to Nucleus