HES2 Antikörper (Hairy and Enhancer of Split 2 (Drosophila)) (Cy5)

Details for Product anti-HES2 Antibody No. ABIN1704679
Antigen
  • HES2
  • bHLHb40
  • HES-2
  • hes family bHLH transcription factor 2
  • hairy and enhancer of split 2 (Drosophila)
  • HES2
  • Hes2
Reaktivität
Human, Maus, Ratte (Rattus)
45
29
29
Wirt
Kaninchen
32
13
Klonalität
Polyklonal
Konjugat
Dieser HES2 Antikörper ist konjugiert mit Cy5
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
26
18
12
6
3
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human HES2
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere HES2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Hes2 (HES2 Antibody Abstract)
Hintergrund

The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.

Synonyms: bHLHb40, Class B basic helix loop helix protein 40, Hairy and enhancer of split 2 Drosophila, Transcription factor HES 2, HES2_HUMAN.

Gen-ID 54626
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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