Androgen Receptor Antikörper (AR) (pSer791) (Cy5)

Details for Product anti-AR Antibody No. ABIN1704526
Antigen
Epitop
pSer791
39
39
32
29
24
22
22
21
20
19
18
15
13
12
9
9
9
9
9
9
8
8
7
6
5
5
4
4
4
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
572
135
113
17
9
4
4
4
4
2
1
1
1
1
Wirt
Kaninchen
414
172
8
2
1
Klonalität
Polyklonal
Konjugat
Dieser Androgen Receptor Antikörper ist konjugiert mit Cy5
35
14
13
13
13
13
13
13
13
9
9
7
5
5
5
5
4
3
3
3
3
3
3
3
3
3
3
3
3
3
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
320
195
168
114
103
66
66
48
21
15
12
10
8
7
7
5
5
3
3
3
1
1
Optionen
Immunogen KLH conjugated synthetic phosphopeptide derived from human Androgen Receptor around the phosphorylation site of Ser791
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Androgen Receptor (AR Antibody Abstract)
Hintergrund

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Synonyms: Androgen Receptor phospho S791, Androgen Receptor Ser791, Androgen Receptor phospho Ser791, p-Androgen Receptor Ser791, ANDR_HUMAN, HYSP1, AIS, Androgen receptor dihydrotestosterone receptor, testicular feminization, spinal and bulbar muscular atrophy, Kennedy disease, AR, DHTR, Dihydro Testosterone Receptor, Dihydrotestosterone receptor, HUMARA, Nuclear receptor subfamily 3 group C member 4, SBMA, SMAX1, Spinal and bulbar muscular atrophy, TFM.

Gen-ID 367
Pathways Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months