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DCLRE1C Antikörper (AA 301-400) (Cy5)

DCLRE1C Reaktivität: Ratte WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal Cy5
Produktnummer ABIN1704476
  • Target Alle DCLRE1C Antikörper anzeigen
    DCLRE1C (DNA Cross-Link Repair 1C (DCLRE1C))
    Bindungsspezifität
    • 14
    • 10
    • 8
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 301-400
    Reaktivität
    • 44
    • 27
    • 24
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Ratte
    Wirt
    • 58
    • 1
    Kaninchen
    Klonalität
    • 59
    Polyklonal
    Konjugat
    • 29
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser DCLRE1C Antikörper ist konjugiert mit Cy5
    Applikation
    • 45
    • 28
    • 23
    • 12
    • 12
    • 8
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Ratte
    Homologie
    Human,Mouse,Cow,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human DCLREC1C/Artemis
    Isotyp
    IgG
    Top Product
    Discover our top product DCLRE1C Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    DCLRE1C (DNA Cross-Link Repair 1C (DCLRE1C))
    Andere Bezeichnung
    DCLREC1C/Artemis (DCLRE1C Produkte)
    Synonyme
    artemis antikoerper, A-SCID antikoerper, DCLREC1C antikoerper, RS-SCID antikoerper, SCIDA antikoerper, SNM1C antikoerper, hSNM1C antikoerper, Snm1l antikoerper, nuclease antikoerper, 9930121L06Rik antikoerper, AI661365 antikoerper, Art antikoerper, DNA cross-link repair 1C antikoerper, DCLRE1C antikoerper, Dclre1c antikoerper
    Hintergrund

    Synonyms: SCIDA, SNM1C, A-SCID, RS-SCID, DCLREC1C, Protein artemis, DNA cross-link repair 1C protein, Protein A-SCID, SNM1 homolog C, hSNM1C, SNM1-like protein, DCLRE1C, ARTEMIS, ASCID

    Background: Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ.

    Gen-ID
    64421
    UniProt
    Q96SD1
    Pathways
    DNA Reparatur
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