FIP1 Like 1 (S. Cerevisiae) (FIP1L1) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704282
Antigen
  • FIP1
  • Rhe
  • hFip1
  • 1300019H17Rik
  • Rje
  • fip1l1
  • wu:fd36f11
  • zgc:103421
  • factor interacting with PAPOLA and CPSF1
  • factor interacting with PAPOLA and CPSF1 S homeolog
  • FIP1 like 1 (S. cerevisiae)
  • FIP1 like 1b (S. cerevisiae)
  • fip1l1
  • FIP1L1
  • fip1l1.S
  • Fip1l1
  • fip1l1b
Reaktivität
Human, Maus, Ratte (Rattus)
40
27
27
5
4
4
3
2
2
1
1
1
Wirt
Kaninchen
36
4
Klonalität
Polyklonal
Konjugat
Cy5
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
28
15
12
11
7
6
3
2
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human FIP1L1
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Fip1l1 (FIP1L1 Antibody Abstract)
Hintergrund

The Component of the Cleavage and Polyadenylation Specificity Factor (CPSF) complex plays an important role in the 3'-end formation of pre-mRNA. This complex recognizes the AAUAAA signal sequence and interacts with poly(A) polymerase to process and add to the poly(A) tail. FIP1L1 (FIP1-like 1), also known as Pre-mRNA 3'-end-processing factor FIP1, FIP1 (Factor interacting with PAP) and RHE (Rearranged in hypereosinophilia), is a 594 amino acid nuclear protein that is a component of the CPSF complex. Within the complex, FIP1L1 contributes to the poly(A) recognition and stimulates poly(A) addition. Fusion of the genes encoding FIP1L1 and PDGFRA due to an interstitial deletion on chromosome 4q12 is the cause of hypereosinophilia syndrome, a rare blood disorder characterized by continuous overproduction of eosinophils in the bone marrow that leads to tissue infiltration and organ damage. There are three isoforms of FIP1L1 that are produced as a result of alternative splicing events.

Synonyms: DKFZp586K0717, Factor interacting with PAP, FIP1, FIP1 like 1 S cerevisiae, FIP1 like 1, FLJ33619, hFip 1, hFip1, Pre mRNA 3 end processing factor FIP1, Rearranged in hypereosinophilia, RHE, FIP1_HUMAN.

Gen-ID 81608
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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