STIP1 Homology and U-Box Containing Protein 1 (STUB1) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704253
Antigen
  • CHIP
  • HSPABP2
  • NY-CO-7
  • SDCCAG7
  • UBOX1
  • 0610033N24Rik
  • 2210017D18Rik
  • 2310040B03Rik
  • AW046544
  • Chip
  • wu:fc22f04
  • zgc:56076
  • STUB1
  • chip
  • STIP1 homology and U-box containing protein 1
  • STIP1 homology and U-Box containing protein 1
  • STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase L homeolog
  • STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
  • STIP1 homology and U box-containing protein 1
  • STUB1
  • Stub1
  • stub1
  • stub1.L
  • LOC100282870
Reaktivität
Human, Maus, Ratte (Rattus)
135
72
67
13
10
8
6
6
6
5
4
4
4
3
2
2
2
2
2
1
1
1
Wirt
Kaninchen
109
22
6
Klonalität
Polyklonal
Konjugat
Cy5
7
5
4
3
3
3
3
3
3
3
3
2
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
101
57
33
19
19
12
5
4
3
2
1
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human CHIP
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Chip (STUB1 Antibody Abstract)
Hintergrund

E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223).

Subcellular location: Cytoplasm, Nucleus

Synonyms: CHIP, UBOX1, SCAR16, HSPABP2, NY-CO-7, SDCCAG7, E3 ubiquitin-protein ligase CHIP, Antigen NY-CO-7, CLL-associated antigen KW-8, Carboxy terminus of Hsp70-interacting protein, STIP1 homology and U box-containing protein 1, STUB1, PP1131

Gen-ID 10273
UniProt Q9UNE7
Pathways Regulation of Hormone Metabolic Process, Response to Water Deprivation
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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