ARID1B Antikörper (AT Rich Interactive Domain 1B (SWI1-Like)) (Cy5)

Details for Product anti-ARID1B Antibody No. ABIN1704160
Antigen
  • fd07d11
  • si:dkey-60a16.3
  • wu:fd07d11
  • 8030481M12
  • 9330189K18Rik
  • AI836955
  • Ardi1b
  • B230217J03Rik
  • mKIAA1235
  • 6A3-5
  • Smcf1
  • smcf-1
  • BAF250B
  • BRIGHT
  • DAN15
  • ELD/OSA1
  • MRD12
  • OSA2
  • P250R
  • AT rich interactive domain 1B (SWI1-like)
  • AT rich interactive domain 1B (SWI-like)
  • AT-rich interaction domain 1B
  • arid1b
  • Arid1b
  • ARID1B
Reaktivität
Human, Maus, Ratte (Rattus)
53
32
19
4
1
1
1
Wirt
Kaninchen
47
6
Klonalität
Polyklonal
Konjugat
Dieser ARID1B Antikörper ist konjugiert mit Cy5
3
3
3
3
3
3
2
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
22
18
15
13
12
11
4
2
2
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human ARID1B
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere ARID1B products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Arid1b (ARID1B Antibody Abstract)
Hintergrund

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically.

Subcellular location: Nucleus

Synonyms: OSA2, 6A3-5, DAN15, MRD12, P250R, BRIGHT, BAF250B, ELD/OSA1, AT-rich interactive domain-containing protein 1B, ARID domain-containing protein 1B, BRG1-associated factor 250b, BRG1-binding protein hELD/OSA1, Osa homolog 2, hOsa2, ARID1B, KIAA1235

Gen-ID 57492
UniProt Q8NFD5
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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