HDAC3 Antikörper (Histone Deacetylase 3) (Cy5)

Details for Product anti-HDAC3 Antibody No. ABIN1704127
Antigen
  • CG2128
  • DHDAC3
  • DmHDAC3
  • Dmel\\CG2128
  • Dromel_CG2128_FBtr0078767_hdac3_mORF
  • HDAC
  • HDAC3
  • Hdac 3
  • dHDAC3
  • dmHDA402
  • hdac3
  • HDm
  • hd3
  • RPD3
  • XRpd3
  • rpd3-2
  • HD3
  • RPD3-2
  • AW537363
  • zgc:55927
  • Histone deacetylase 3
  • histone deacetylase 3
  • histone deacetylase 3 S homeolog
  • HDAC3
  • hdac3
  • CNL05260
  • Hdac3
  • hdac3.S
Reaktivität
Human, Maus, Ratte (Rattus)
286
140
123
12
12
11
9
8
6
6
6
3
2
1
1
1
1
1
Wirt
Kaninchen
214
68
5
Klonalität
Polyklonal
Konjugat
Dieser HDAC3 Antikörper ist konjugiert mit Cy5
11
7
7
7
7
7
7
6
6
2
2
2
2
2
2
2
2
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
217
111
103
59
41
27
25
16
15
12
4
3
2
1
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human HDAC3/HD3
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere HDAC3 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung HDAC3/HD3 (HDAC3 Antibody Abstract)
Hintergrund

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1, increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.

Subcellular location: Nucleus

Synonyms: HD3, RPD3, RPD3-2, Histone deacetylase 3, SMAP45, HDAC3

Gen-ID 8841
UniProt O15379
Pathways Neurotrophin Signalübertragung, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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