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Allergin-1 Antikörper (AA 61-160) (Cy5)

This anti-Allergin-1 antibody (ABIN1703821) is a Rabbit Polyclonal antibody detecting Allergin-1 in IF (cc), IF (p). Suitable for Human.
Produktnummer ABIN1703821

Quick Overview for Allergin-1 Antikörper (AA 61-160) (Cy5) (ABIN1703821)

Target

Alle Allergin-1 (MILR1) Antikörper anzeigen
Allergin-1 (MILR1) (Mast Cell Immunoglobulin-Like Receptor 1 (MILR1))

Reaktivität

  • 26
  • 3
Human

Wirt

  • 23
  • 4
  • 1
Kaninchen

Klonalität

  • 24
  • 4
Polyklonal

Konjugat

  • 8
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Allergin-1 Antikörper ist konjugiert mit Cy5

Applikation

  • 12
  • 12
  • 10
  • 6
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 61-160

    Homologie

    Human

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human Allergin-1

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    Allergin-1 (MILR1) (Mast Cell Immunoglobulin-Like Receptor 1 (MILR1))

    Andere Bezeichnung

    Allergin-1

    Hintergrund

    Synonyms: C17orf60,Chromosome 17 open reading frame 60.

    Background: As a major event in type allergic reaction,degranulation of mast cells is triggered by the interaction between specific IgEs and high affinity IgE receptors (FcRIs) on mast cell membrane,and is followed by the release of a battery of inflammatory mediators,such as histamine,leukotrienes and arachidonic acid,and these inflammatory mediators in turn induce a series of allergic symptoms.Recently,Allergin-1 has been found to be an immunoglobulin-like receptor preferentially expressed on mast cells.The crosslinking of Allergin-1 to FcRIs on mast cells may inhibit the signal transduction from FcRIs to intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM),generate ITIM inhibitory signals,which then participate in the regulation of mast cell degranulation,and finally block the initiation of allergic inflammation.

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