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WDFY1 Antikörper (AA 21-120) (Cy3)

This anti-WDFY1 antibody (ABIN1703066) is a Rabbit Polyclonal antibody detecting WDFY1 in FACS, IF (cc), IF (p). Suitable for Rat.
Produktnummer ABIN1703066

Quick Overview for WDFY1 Antikörper (AA 21-120) (Cy3) (ABIN1703066)

Target

Alle WDFY1 Antikörper anzeigen
WDFY1 (WD Repeat and FYVE Domain Containing 1 (WDFY1))

Reaktivität

  • 21
  • 20
  • 6
  • 4
  • 4
  • 4
  • 4
  • 3
  • 2
  • 1
  • 1
Ratte

Wirt

  • 35
  • 1
Kaninchen

Klonalität

  • 36
Polyklonal

Konjugat

  • 12
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser WDFY1 Antikörper ist konjugiert mit Cy3

Applikation

  • 14
  • 12
  • 12
  • 12
  • 10
  • 5
  • 3
  • 3
  • 1
Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 15
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    AA 21-120

    Kreuzreaktivität

    Ratte

    Homologie

    Human,Mouse,Dog,Cow,Pig,Horse,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human WDFY1

    Isotyp

    IgG
  • Applikationshinweise

    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    WDFY1 (WD Repeat and FYVE Domain Containing 1 (WDFY1))

    Andere Bezeichnung

    WDFY1 + WDFY2

    Hintergrund

    Synonyms: FENS 1, FENS-1, FENS1, KIAA1435, Phosphoinositide binding protein 1, Phosphoinositide binding protein SR1, Phosphoinositide-binding protein 1, WD repeat and FYVE domain containing 1, WD repeat and FYVE domain-containing protein 1, WD40 and FYVE domain containing protein 1, WD40- and FYVE domain-containing protein 1, WDF1, WDFY1, WDFY1_HUMAN, ZFYVE17, Zinc finger FYVE domain containing protein 17, Zinc finger FYVE domain-containing protein 17, WDFY2, WD repeat and FYVE domain-containing protein 2, Propeller-FYVE protein, WD40- and FYVE domain-containing protein 2, Zinc finger FYVE domain-containing protein 22, WDF2, ZFYVE22

    Background: WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. WDFY1 positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. WDFY1 Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines. WDFY2 acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. WDFY2 positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1

    Gen-ID

    57590, 115825

    UniProt

    Q8IWB7, Q96P53
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