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PRAM1 Antikörper (AA 551-650) (Cy3)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PRAM1 in IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN1702195

Kurzübersicht für PRAM1 Antikörper (AA 551-650) (Cy3) (ABIN1702195)

Target

Alle PRAM1 Antikörper anzeigen
PRAM1 (PML-RARA Regulated Adaptor Molecule 1 (PRAM1))

Reaktivität

  • 20
  • 1
Human

Wirt

  • 18
  • 1
  • 1
Kaninchen

Klonalität

  • 20
Polyklonal

Konjugat

  • 7
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PRAM1 Antikörper ist konjugiert mit Cy3

Applikation

  • 12
  • 12
  • 6
  • 5
  • 4
  • 3
  • 1
  • 1
  • 1
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 2
    • 1
    • 1
    • 1
    AA 551-650

    Kreuzreaktivität

    Human

    Homologie

    Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human PRAM1

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    PRAM1 (PML-RARA Regulated Adaptor Molecule 1 (PRAM1))

    Andere Bezeichnung

    PRAM1

    Hintergrund

    Synonyms: PML RAR, PML RARA regulated adaptor molecule 1, PML RARA target gene encoding an Adaptor Molecule 1, PML-RARA-regulated adapter molecule 1, PRAM 1, PRAM, PRAM-1, PRAM_HUMAN, PRAM1.

    Background: Complete remission of acute promyelocytic leukemia can be achieved by treating patients with retinoic acid, and PML-RAR-a (promyelocytic leukemia-retinoic acid receptor alpha fusion protein) plays a major role in mediating retinoic acid effects in leukemia cells. The retinoic acid-induced gene, PRAM-1 (PML-RAR-a target gene encoding an adaptor molecule 1) encodes an adaptor protein which is expressed and modulated during normal human myelopoiesis. PRAM-1 expression is hindered by expression of PML-RAR-a. The 718 amino acid PRAM-1 protein contains eight N-terminal proline-rich repeats and several proline residues that are clustered as type I or type II SH3 recognition motifs. PRAM-1 demonstrates expression in hematopoietic tissues and lung.

    Pathways

    Regulation of Leukocyte Mediated Immunity
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