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PRAM1 Antikörper (AA 551-650) (Biotin)

PRAM1 Reaktivität: Human ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN1700382
  • Target Alle PRAM1 Antikörper anzeigen
    PRAM1 (PML-RARA Regulated Adaptor Molecule 1 (PRAM1))
    Bindungsspezifität
    • 14
    • 2
    • 1
    • 1
    AA 551-650
    Reaktivität
    • 19
    • 1
    Human
    Wirt
    • 17
    • 1
    • 1
    Kaninchen
    Klonalität
    • 19
    Polyklonal
    Konjugat
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PRAM1 Antikörper ist konjugiert mit Biotin
    Applikation
    • 13
    • 13
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human
    Homologie
    Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human PRAM1
    Isotyp
    IgG
    Top Product
    Discover our top product PRAM1 Primärantikörper
  • Applikationshinweise
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    PRAM1 (PML-RARA Regulated Adaptor Molecule 1 (PRAM1))
    Andere Bezeichnung
    PRAM1 (PRAM1 Produkte)
    Synonyme
    PRAM1 antikoerper, AY665714 antikoerper, PML-RAR antikoerper, PRAM-1 antikoerper, RGD1564330 antikoerper, PML-RARA regulated adaptor molecule 1 antikoerper, PML-RAR alpha-regulated adaptor molecule 1 antikoerper, PRAM1 antikoerper, Pram1 antikoerper
    Hintergrund

    Synonyms: PML RAR, PML RARA regulated adaptor molecule 1, PML RARA target gene encoding an Adaptor Molecule 1, PML-RARA-regulated adapter molecule 1, PRAM 1, PRAM, PRAM-1, PRAM_HUMAN, PRAM1.

    Background: Complete remission of acute promyelocytic leukemia can be achieved by treating patients with retinoic acid, and PML-RAR-a (promyelocytic leukemia-retinoic acid receptor alpha fusion protein) plays a major role in mediating retinoic acid effects in leukemia cells. The retinoic acid-induced gene, PRAM-1 (PML-RAR-a target gene encoding an adaptor molecule 1) encodes an adaptor protein which is expressed and modulated during normal human myelopoiesis. PRAM-1 expression is hindered by expression of PML-RAR-a. The 718 amino acid PRAM-1 protein contains eight N-terminal proline-rich repeats and several proline residues that are clustered as type I or type II SH3 recognition motifs. PRAM-1 demonstrates expression in hematopoietic tissues and lung.

    Pathways
    Regulation of Leukocyte Mediated Immunity
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