C5 Antikörper (Cy3)

Produktnummer ABIN1702038

Der Cy3-konjugierte Kaninchen Polyklonal anti-C5 Antikörper (ABIN1702038) detektiert spezifisch C5 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für C5 Antikörper (Cy3) (ABIN1702038)

Target: C5 (Complement Component 5 (C5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C5 Antikörper ist konjugiert mit Cy3

Applikation: Western Blotting (WB)

Produktdetails anti-C5 Antikörper (Cy3)

Verwendungszweck: Complement C5b Polyclonal Antibody, Cy3 Conjugated

Kreuzreaktivität: Human

Homologie: Mouse,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human C5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:300-5000)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu C5

Target: C5 (Complement Component 5 (C5))

Hintergrund:

Synonyms: Complement C5,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4,Complement C5 alpha chain,Complement C5 alpha' chain

Background: The complement component proteins: C2, C3, C4 and C5 are potent anaphyl-atoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. Activation of the complement system leads to the formation of C5b-9 terminal complex, and while C5b-9 can promote cell lysis, the sublytic assembly of C5b-9 on plasma membranes causes an opposite result and induces cell cycle activation and survival. C5b-9 can rescue oligodendrocytes from FAS-mediated apoptosis by regulating caspase-8 processing via PI 3-K signaling. C5b-9 may play a pro-inflammatory role in the acute phase of multiple sclerosis, but may also be neuroprotective during the chronic phase of the disease. Complement C5 precursor contains C5a anaphylatoxin. C3a and C5a secretion correlates with pathophysiological phenotypes such as asthma and bacterial meningitis.

Gen-ID: 727

UniProt: P01031

Pathways: Komplementsystem, Carbohydrate Homeostasis