FZR1 Antikörper (AA 141-240) (Biotin)

Produktnummer ABIN1700670

Dieser Anti-FZR1 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von FZR1 in WB, ELISA, IHC (p) und IHC (fro). Geeignet für Human und Maus.

Kurzübersicht für FZR1 Antikörper (AA 141-240) (Biotin) (ABIN1700670)

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FZR1 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-FZR1 Antikörper (Biotin)

Bindungsspezifität: AA 141-240

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Sheep,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FZR1/CDC20C

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu FZR1

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Andere Bezeichnung: FZR1/CDC20C

Hintergrund:

Synonyms: FZR, FZR2, CDC20C, Fizzy-related protein homolog, CDC20-like protein 1, Cdh1/Hct1 homolog, FZR1, FYR, KIAA1242

Background: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Gen-ID: 51343

UniProt: Q9UM11

Pathways: DNA Replication, Synthesis of DNA