C5 Antikörper (Biotin)

Produktnummer ABIN1700225

Der Kaninchen Polyklonal Anti-C5-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, C5 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für C5 Antikörper (Biotin) (ABIN1700225)

Target: C5 (Complement Component 5 (C5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C5 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-C5 Antikörper (Biotin)

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human C5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:100-1000), IHC-P(1:100-500)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at 4°C

Haltbarkeit: 12 months

Details zu C5

Target: C5 (Complement Component 5 (C5))

Hintergrund:

The complement component proteins: C2, C3, C4 and C5 are potent anaphyl-atoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. Activation of the complement system leads to the formation of C5b-9 terminal complex, and while C5b-9 can promote cell lysis, the sublytic assembly of C5b-9 on plasma membranes causes an opposite result and induces cell cycle activation and survival. C5b-9 can rescue oligodendrocytes from FAS-mediated apoptosis by regulating caspase-8 processing via PI 3-K signaling. C5b-9 may play a pro-inflammatory role in the acute phase of multiple sclerosis, but may also be neuroprotective during the chronic phase of the disease. Complement C5 precursor contains C5a anaphylatoxin. C3a and C5a secretion correlates with pathophysiological phenotypes such as asthma and bacterial meningitis.

Synonyms: Anaphylatoxin C5a analog, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, C5, C5a, CO5_HUMAN, Complement C5 alpha'' chain, Complement C5, Complement component C5, CPAMD4.

Gen-ID: 727

Pathways: Komplementsystem, Carbohydrate Homeostasis