Allergin-1 Antikörper (AA 61-160) (Biotin)

Produktnummer ABIN1700197

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Allergin-1 in ELISA, IHC (fro) und IHC (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Allergin-1 Antikörper (AA 61-160) (Biotin) (ABIN1700197)

Target: Allergin-1 (MILR1) (Mast Cell Immunoglobulin-Like Receptor 1 (MILR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Allergin-1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Allergin-1 Antikörper (Biotin)

Bindungsspezifität: AA 61-160

Homologie: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Allergin-1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu Allergin-1

Target: Allergin-1 (MILR1) (Mast Cell Immunoglobulin-Like Receptor 1 (MILR1))

Andere Bezeichnung: Allergin-1

Hintergrund:

Synonyms: C17orf60,Chromosome 17 open reading frame 60.

Background: As a major event in type allergic reaction,degranulation of mast cells is triggered by the interaction between specific IgEs and high affinity IgE receptors (FcRIs) on mast cell membrane,and is followed by the release of a battery of inflammatory mediators,such as histamine,leukotrienes and arachidonic acid,and these inflammatory mediators in turn induce a series of allergic symptoms.Recently,Allergin-1 has been found to be an immunoglobulin-like receptor preferentially expressed on mast cells.The crosslinking of Allergin-1 to FcRIs on mast cells may inhibit the signal transduction from FcRIs to intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM),generate ITIM inhibitory signals,which then participate in the regulation of mast cell degranulation,and finally block the initiation of allergic inflammation.