EYA3 Antikörper (AA 371-470) (AbBy Fluor® 555)

Produktnummer ABIN1697621

Der Kaninchen Polyklonal Anti-EYA3-Antikörper wurde für WB, IF (cc) und IF (p) validiert. Er ist geeignet, EYA3 in Proben von Human zu detektieren.

Kurzübersicht für EYA3 Antikörper (AA 371-470) (AbBy Fluor® 555) (ABIN1697621)

Target: EYA3 (Eyes Absent Homolog 3 (EYA3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EYA3 Antikörper ist konjugiert mit AbBy Fluor® 555

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-EYA3 Antikörper (AbBy Fluor® 555)

Bindungsspezifität: AA 371-470

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EYA3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu EYA3

Target: EYA3 (Eyes Absent Homolog 3 (EYA3))

Andere Bezeichnung: EYA3

Hintergrund:

Synonyms: AI844637, DKFZp686C132, EYA3, EYA3_HUMAN, Eyes absent 3, Eyes absent 3 homolog Drosophila, Eyes absent homolog 3, OTTMUSP00000010370, RP11-460I13.4, RP23-442A20.1.

Background: EYA3 is a 573 amino acid protein that localizes to both the nucleus and the cytoplasm and is one of several mammalian homologs of the Drosophila Eya (eyes absent) protein. Existing as two alternatively spliced isoforms, EYA3 possesses magnesium-catalyzed phosphatase activity and is thought to play a role in transcriptional regulation during organogenesis. Specifically, EYA3 interacts with proteins such as Six1 and, via this interaction, functions to activate the expression of genes that are involved in cellular proliferation and organ development. Upon DNA damage, EYA3 may be phosphorylated by ATM or ATR. The gene encoding EYA3 maps to chromosome 1, which spans about 260 million base pairs and comprises nearly 8 % of the human genome.

Gen-ID: 2140

Pathways: Positive Regulation of Response to DNA Damage Stimulus