FAN1 Antikörper (AbBy Fluor® 488)

Produktnummer ABIN1695206

Produktdetails anti-FAN1 Antikörper (AbBy Fluor® 488)

Target: FAN1 (FANCD2/FANCI-Associated Nuclease 1 (FAN1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAN1 Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FAN1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 4°C

Haltbarkeit: 12 months

Details zu FAN1

Target: FAN1 (FANCD2/FANCI-Associated Nuclease 1 (FAN1))

Andere Bezeichnung: Fan1 (FAN1 Produkte)

Hintergrund:

Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).

Subcellular location: Nucleus

Synonyms: KMIN, hFAN1, MTMR15, KIAA1018, Fanconi-associated nuclease 1, FANCD2/FANCI-associated nuclease 1, Myotubularin-related protein 15, FAN1

Gen-ID: 22909

UniProt: Q9Y2M0

Pathways: DNA Reparatur