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PRAM1 Antikörper (AA 551-650) (Alexa Fluor 350)

PRAM1 Reaktivität: Human IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 350
Produktnummer ABIN1693115
$438.15
Zzgl. Versandkosten $45.00
100 μL
Lieferung in 11 bis 16 Werktagen
  • Target Alle PRAM1 Antikörper anzeigen
    PRAM1 (PML-RARA Regulated Adaptor Molecule 1 (PRAM1))
    Bindungsspezifität
    • 14
    • 7
    • 1
    • 1
    • 1
    AA 551-650
    Reaktivität
    • 26
    • 1
    Human
    Wirt
    • 18
    • 7
    • 1
    Kaninchen
    Klonalität
    • 26
    Polyklonal
    Konjugat
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PRAM1 Antikörper ist konjugiert mit Alexa Fluor 350
    Applikation
    • 12
    • 12
    • 11
    • 10
    • 3
    • 3
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human PRAM1
    Isotyp
    IgG
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C/-80 °C
    Informationen zur Lagerung
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Haltbarkeit
    12 months
  • Target
    PRAM1 (PML-RARA Regulated Adaptor Molecule 1 (PRAM1))
    Andere Bezeichnung
    PRAM1 (PRAM1 Produkte)
    Synonyme
    PRAM1, AY665714, PML-RAR, PRAM-1, RGD1564330, PML-RARA regulated adaptor molecule 1, PML-RAR alpha-regulated adaptor molecule 1, PRAM1, Pram1
    Hintergrund

    Complete remission of acute promyelocytic leukemia can be achieved by treating patients with retinoic acid, and PML-RAR-a (promyelocytic leukemia-retinoic acid receptor alpha fusion protein) plays a major role in mediating retinoic acid effects in leukemia cells. The retinoic acid-induced gene, PRAM-1 (PML-RAR-a target gene encoding an adaptor molecule 1) encodes an adaptor protein which is expressed and modulated during normal human myelopoiesis. PRAM-1 expression is hindered by expression of PML-RAR-a. The 718 amino acid PRAM-1 protein contains eight N-terminal proline-rich repeats and several proline residues that are clustered as type I or type II SH3 recognition motifs. PRAM-1 demonstrates expression in hematopoietic tissues and lung.

    Subcellular location: Cell membrane

    Synonyms: PML RAR, PML RARA regulated adaptor molecule 1, PML RARA target gene encoding an Adaptor Molecule 1, PML-RARA-regulated adapter molecule 1, PRAM 1, PRAM, PRAM-1, PRAM_HUMAN, PRAM1.

    Pathways
    Regulation of Leukocyte Mediated Immunity
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