PR Antikörper

Produktnummer ABIN1689598

Dieser Maus Monoklonal Antikörper detektiert spezifisch PR in WB, ELISA und IHC. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 5+ Publikationen zitiert.

Kurzübersicht für PR Antikörper (ABIN1689598)

Target: PR

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Klon: 2F12B4-2F12H2

Produktdetails

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of PR expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen

Jowett: "Safe Motherhood interventions in low-income countries: an economic justification and evidence of cost effectiveness." in: Health policy (Amsterdam, Netherlands), Vol. 53, Issue 3, pp. 201-28, (2000) (PubMed).

Hagen, Silva, Amorim, Hagedoorn, Wassink, Haaker, Robb: "Novel structure and redox chemistry of the prosthetic groups of the iron-sulfur flavoprotein sulfide dehydrogenase from Pyrococcus furiosus; evidence for a [2Fe-2S] cluster with Asp(Cys)3 ligands." in: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, Vol. 5, Issue 4, pp. 527-34, (2000) (PubMed).

Wen, Xu, Mais, Goldman, McDonnell: "The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells." in: Molecular and cellular biology, Vol. 14, Issue 12, pp. 8356-64, (1994) (PubMed).

McGuire: "Prognostic factors in primary breast cancer." in: Cancer surveys, Vol. 5, Issue 3, pp. 527-36, (1987) (PubMed).

Bach: "Markets in kidneys." in: Lancet, Vol. 2, Issue 8411, pp. 1102, (1984) (PubMed).

Antigendetails

Target: PR

Hintergrund: PR(progesterone receptor), with 933-amino acid protein (about 110kDa), a member of the steroid receptor superfamily, mediates the physiologic effects of progesterone, PR is mediated by two functionally different isoforms of the progesterone receptor, the full length PR-B and the short form PR-A. The PR-A and PR-B proteins are 94 kDa and 114 kDa respectively. That are equimolar in the normal breast but dysregulated in advanced disease. PR is prognostic markers in breast cancers irrespective of the patient's progestational status Human progesterone.
Synonyms: PR, NR3C3, PGR

Gen-ID: 5241