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GIT1 Antikörper (AA 375-770)

GIT1 Reaktivität: Ratte ICC, IF, IP, WB Wirt: Maus Monoclonal S39B-8 unconjugated
Produktnummer ABIN1686622
$474.50
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 3 bis 4 Werktagen
  • Target Alle GIT1 Antikörper anzeigen
    GIT1
    Bindungsspezifität
    • 17
    • 15
    • 15
    • 15
    • 15
    • 12
    • 10
    • 7
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 375-770
    Reaktivität
    • 95
    • 45
    • 37
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 122
    • 14
    Maus
    Klonalität
    • 114
    • 22
    Monoklonal
    Konjugat
    • 38
    • 11
    • 10
    • 10
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    Dieser GIT1 Antikörper ist unkonjugiert
    Applikation
    • 56
    • 52
    • 52
    • 39
    • 21
    • 20
    • 17
    • 17
    • 15
    • 13
    • 12
    • 2
    • 2
    • 1
    • 1
    Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
    Spezifität
    Detects ~90 kDa. Does not cross-react with GIT2.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Fusion protein amino acids 375-770 (C-terminus) of rat GIT1
    Klon
    S39B-8
    Isotyp
    IgG1
  • Applikationshinweise
    • WB (1:1000)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN1686622 was sufficient for detection of GIT1 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C
  • Target
    GIT1
    Andere Bezeichnung
    GIT1 (GIT1 Produkte)
    Synonyme
    Cat-1, p95Cat, GIT ArfGAP 1, G protein-coupled receptor kinase interacting ArfGAP 1, G protein-coupled receptor kinase-interactor 1, GIT1, Git1
    Hintergrund
    G-protein coupled receptor (GPCR) kinase interacting proteins 1 and 2 (GIT-1 and GIT-2) are highly conserved, ubiquitous scaffold proteins involved in localized signaling to help regulate focal contact assembly and cytoskeletal dynamics. GIT proteins contain multiple interaction domains that allow interaction with small GTPases (including ARF, Rac and cdc42), kinases (such as PAK and MEK), the Rho family GEF PIX, and the focal adhesion protein paxillin (reviewed in 1). GIT-1 is localized to focal adhesions, cytoplasmic complexes and membrane protrusions, and regulates cell protrusion formation and cell migration (2). GIT-1 has also been implicated in neuronal functions including synapse formation (3) and the pathology of Huntington disease (4). Huntington disease is a genetic neurodegenerative condition involving a mutation in the huntington gene. The huntington gene product (htt) is ubiquitinated and degraded in human Huntington disease brains (5). Htt interacts directly with GIT-1 causing enhanced htt proteolysis, indicating that GIT-1 distribution and function may contribute to Huntington disease pathology (4).
    Gen-ID
    83709
    NCBI Accession
    NP_114002
    UniProt
    Q9Z272
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