SETD2 Antikörper (AA 803-1103)

Produktnummer ABIN1682666

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SETD2 in WB und IF. Er zeigt eine Reaktivität gegenüber Human und wurde in 4+ Publikationen erwähnt.

Kurzübersicht für SETD2 Antikörper (AA 803-1103) (ABIN1682666)

Target: SETD2 (SET Domain Containing 2 (SETD2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SETD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-SETD2 Antikörper

Bindungsspezifität: AA 803-1103

Sequenz: SLCNSEAENI EPSVMKISSN SFMNVHLESK PVICDSRNLT DHSKFACEEY KQSIGSTSSA SVNHFDDLYQ PIGSSGIASS LQSLPPGIKV DSLTLLKCGE NTSPVLDAVL KSKKSSEFLK HAGKETIVEV GSDLPDSGKG FASRENRRNN GLSGKCLQEA QEEGNSILPE RRGRPEISLD ERGEGGHVHT SDDSEVVFSS CDLNLTMEDS DGVTYALKCD SSGHAPEIVS TVHEDYSGSS ESSNDESDSE DTDSDDSSIP RNRLQSVVVV PKNSTLPMEE TSPCSSRSSQ SYRHYSDHWE D

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 803-1103 of human SETD2 (NP_054878.5).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-SETD2 Antikörper (ABIN1682666)

Huang, Gu, Li: "H3K36me3-mediated mismatch repair preferentially protects actively transcribed genes from mutation." in: The Journal of biological chemistry, Vol. 293, Issue 20, pp. 7811-7823, (2019) (PubMed).

Jia, Long, Miron, Yin, Wei, Zhang, Wu: "Setd2 is associated with strontium-induced bone regeneration." in: Acta biomaterialia, Vol. 53, pp. 495-505, (2018) (PubMed).

Chen, Liu, Liu, Xia, Zhang, Han, Jiang, Wang, Cao: "Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity." in: Cell, Vol. 170, Issue 3, pp. 492-506.e14, (2017) (PubMed).

Zhu, Lei, Ju, Wang, Huang, Yang, Shao, Zhu, Wei, Fu, Li, Wu: "SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing." in: Nucleic acids research, Vol. 45, Issue 1, pp. 92-105, (2017) (PubMed).

Details zu SETD2

Target: SETD2 (SET Domain Containing 2 (SETD2))

Andere Bezeichnung: SETD2

Hintergrund: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.,SETD2,HBP231,HIF-1,HIP-1,HSPC069,HYPB,KMT3A,LLS,SET2,p231HBP,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Methylation,SETD2

Molekulargewicht: 175 kDa/192 kDa/287 kDa

Gen-ID: 29072

UniProt: Q9BYW2

Pathways: Tube Formation