LRP2 Antikörper (AA 4446-4655)

Produktnummer ABIN1680712

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch LRP2 in IHC und WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für LRP2 Antikörper (AA 4446-4655) (ABIN1680712)

Target: LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRP2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Produktdetails anti-LRP2 Antikörper

Bindungsspezifität: AA 4446-4655

Sequenz: FHYRRTGSLL PALPKLPSLS SLVKPSENGN GVTFRSGADL NMDIGVSGFG PETAIDRSMA MSEDFVMEMG KQPIIFENPM YSARDSAVKV VQPIQVTVSE NVDNKNYGSP INPSEIVPET NPTSPAADGT QVTKWNLFKR KSKQTTNFEN PIYAQMENEQ KESVAATPPP SPSLPAKPKP PSRRDPTPTY SATEDTFKDT ANLVKEDSEV

Kreuzreaktivität: Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 4446-4655 of human LRP2 (NP_004516.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:200 - 1:1000,IHC,1:20 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu LRP2

Target: LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))

Andere Bezeichnung: LRP2

Hintergrund: The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling, extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).,LRP2,DBS,GP330,Cancer,Cell Biology & Developmental Biology,Endocrine & Metabolism,Lipid Metabolism,Endocrine and metabolic diseases,Obesity,Stem Cells,Cardiovascular,Lipids,Fatty Acids,LRP2

Molekulargewicht: 521 kDa

Gen-ID: 4036

UniProt: P98164

Pathways: Metabolism of Steroid Hormones and Vitamin D, Thyroid Hormone Synthesis, Hormone Transport