TEK Antikörper

Produktnummer ABIN1589942

Der Kaninchen-Polyklonal Anti-TEK-Antikörper wurde für WB validiert. Er ist geeignet zum Nachweis von TEK in Proben aus Maus. }

Kurzübersicht für TEK Antikörper (ABIN1589942)

Target: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TEK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TEK Antikörper

Verwendungszweck: TIE-2 antibody

Spezifität: Recombinant mouse sTIE-2

Produktmerkmale: Chromosomal location: 4 C5, 4 43.34 cM

Aufreinigung: Protein A purified

Immunogen: Recombinant mouse sTIE-2 (ABIN1589755)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: use at 2-5 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Handhabung: Centrifuge vial prior to opening.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Haltbarkeit: 24 months

Details zu TEK

Target: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Andere Bezeichnung: TIE-2

Hintergrund: Angiopoietin-1 receptor, Endothelial tyrosine kinase, HYK, STK1, Tunica interna endothelial cell kinase, Tyrosine kinase with Ig and EGF homology domains-2, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, p140 TEK, CD202b, Tek, Hyk, Tie2, AA517024,Tie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2. Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Tie-2 is a receptor for the angiopoietin (ANG) family: ANG-1, ANG-2, and ANG-3 (mouse)/-4 (human). Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects.

Gen-ID: 21687

NCBI Accession: NM_013690, NP_038718

UniProt: Q02858

Pathways: RTK Signalweg, Growth Factor Binding