TEK Antikörper

Produktnummer ABIN1589890

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TEK in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TEK Antikörper (ABIN1589890)

Target: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TEK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TEK Antikörper

Verwendungszweck: TIE-2 antibody

Spezifität: Recombinant human sTIE-2

Produktmerkmale: Chromosomal location: 9p21

Aufreinigung: Protein A purified

Immunogen: Recombinant human sTIE-2 (ABIN1589753)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: Use 2-5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Handhabung: Centrifuge vial prior to opening.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Haltbarkeit: 24 months

Details zu TEK

Target: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Andere Bezeichnung: TIE-2

Hintergrund: TEK, TIE2, VMCM, TIE-2, VMCM1, CD202B,TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/TEK comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Two ligands, angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2), which bind TIE-2 with high affinity have been identified. Ang2 has been reported to act as an antagonist for Ang1. Mice engineered to overexpress Ang2 or to lack Ang1 or TIE-2 display similar angiogenic defects.

Gen-ID: 7010

NCBI Accession: NM_000459, NP_000450

UniProt: Q02763

Pathways: RTK Signalweg, Growth Factor Binding