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KDM5D Antikörper

Dieses Anti-KDM5D-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von KDM5D in WB. Geeignet für Human.
Produktnummer ABIN1589829

Kurzübersicht für KDM5D Antikörper (ABIN1589829)

Target

Alle KDM5D Antikörper anzeigen
KDM5D (Lysine (K)-Specific Demethylase 5D (KDM5D))

Reaktivität

Human

Wirt

  • 5
  • 1
Kaninchen

Klonalität

  • 5
  • 1
Polyklonal

Konjugat

  • 6
Dieser KDM5D Antikörper ist unkonjugiert

Applikation

  • 6
  • 4
  • 2
  • 1
Western Blotting (WB)
  • Verwendungszweck

    SMCY/JARID1D antibody

    Spezifität

    Recombinant human SMCY

    Produktmerkmale

    Chromosomal location: Yq11, Yq11

    Aufreinigung

    Protein A purified

    Immunogen

    Recombinant human SMCY

    Isotyp

    IgG
  • Applikationshinweise

    Western Blot: Use 1-5 μg/mL

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

    Buffer

    PBS

    Handhabung

    Centrifuge vial prior to opening.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

    Haltbarkeit

    24 months
  • Target

    KDM5D (Lysine (K)-Specific Demethylase 5D (KDM5D))

    Andere Bezeichnung

    SMCY/JARID1D

    Hintergrund

    KDM5D lysine (K)-specific demethylase 5D, HY, HYA,H-Y antigen is defined as a male histocompatibility antigen that causes rejection of male skin grafts by female recipients of the same inbred strain of rodents. Male-specific, or H-Y antigen(s), are also detected by cytotoxic T cells and antibodies. H-Y antigen appears to be an integral part of the membrane of most male cells. In addition, H-Y antibodies detect a soluble form of H-Y that is secreted by the testis. The gene (Smcy/SMCY) coding for H-Y antigen detected by T cells has been cloned. It is expressed ubiquitously in male mice and humans, and encodes an epitope that triggers a specific T-cell response in vitro. Additional epitopes coded for by different Y-chromosomal genes are probably required in vivo for the rejection of male grafts by female hosts. The molecular nature of H-Y antigen detected by antibodies on most male cells is not yet known. Testis-secreted, soluble H-Y antigen, however, was found to be identical to Müllerian-inhibiting substance (MIS). MIS cross-reacts with H-Y antibodies and identical findings were obtained for soluble H-Y antigen and MIS, i.e., secretion by testicular Sertoli and, to a lesser degree, ovarian cells, binding to a gonad-specific receptor, induction of gonadal sex reversal in vitro and, in cattle, in vivo. H-Y antisera also detect a molecule or molecules associated with the heterogametic sex in non-mammalian vertebrates. Molecular data on this antigen or antigens are not yet available.

    Gen-ID

    8284

    NCBI Accession

    NM_001146705, NP_001140177

    UniProt

    Q9BY66

    Pathways

    Warburg Effekt
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