FLT1 Antikörper (Soluble)

Produktnummer ABIN1589805

Dieses Anti-FLT1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FLT1 in WB. Geeignet für Human.

Kurzübersicht für FLT1 Antikörper (Soluble) (ABIN1589805)

Target: FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FLT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FLT1 Antikörper

Bindungsspezifität: Soluble

Verwendungszweck: VEGFR-1/Flt-1 (Peptide), soluble antibody

Spezifität: Peptide: GEHCNKKAVFSRISKFKSTR NDSTTQSNVKH.

Produktmerkmale: Chromosomal location: 13q12
Produced from sera of rabbits immunised with a peptide of the C-terminal end of native human soluble VEGFR-1/Flt-1 (CNKKAVFSRISKFKSTRNDSTTQSNVKH).

Aufreinigung: Anti-human soluble VEGFR-1/Flt-1 was purified by affinity chromatography with immobilized Protein A.

Immunogen: Peptide: GEHCNKKAVFSRISKFKSTR NDSTTQSNVKH.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: Use 1-5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Handhabung: Centrifuge vial prior to opening.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Haltbarkeit: 24 months

Details zu FLT1

Target: FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

Andere Bezeichnung: VEGFR-1/Flt-1

Hintergrund: Soluble vascular endothelial growth factor receptor-1, soluble FLT1, soluble FLT, soluble VEGF receptor 1,Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes, dendritic cells and on trophoblast cells. The flt-1 gene was first described in 1990. The receptor contains seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular splited tyrosine kinase domain. Compared to VEGFR-2 the Flt-1 receptor has a higher affinity for VEGF but a weaker signaling activity. VEGFR-1 thus leads not to proliferation of endothelial cells, but mediates signals for differentiation. Interestingly a naturally occuring soluble variant of VEGFR-1 (sVEGFR-1) was found in HUVEC supernatants in 1996, which is generated by alternative splicing of the flt-1 mRNA.

Gen-ID: 2321

NCBI Accession: NM_001159920, NP_001153392

UniProt: P17948

Pathways: RTK Signalweg, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals