beta Amyloid Antikörper

Produktnummer ABIN1580412

Dieses Anti-beta Amyloid-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von beta Amyloid in WB, IHC, IF und ICC. Geeignet für Human.

Kurzübersicht für beta Amyloid Antikörper (ABIN1580412)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser beta Amyloid Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Klon: AB9

Produktdetails anti-beta Amyloid Antikörper

Aufreinigung: affinity purified antibody

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: The antibody solution can be used at dilutions of 1:1,000 or higher in immunofluorescence experiments. In western blotting using chemiluminescence it can be used at dilutions of 1:1,000-2,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4°C short term or -20°C long term.

Details zu beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Hintergrund: Alzheimer's disease (AD) is a serious and common age related dementia which is characterized by the formation of senile plaques and neurofibrillary tangles. Senile plaques are extracellular accumulations of insoluble proteins found in cortical regions. A major component of senile plaques is beta,-amyloid, a.k.a. Abeta, a peptide predominantly of 42 or 40 amino acids. The Abeta, peptide is derived from a section of the membrane spanning domain and the immediate extracellular region of a much larger protein called the amyloid precursor protein (APP). This is an abundant protein of poorly understood function. The Abeta, peptides are generated by the activity of proteases called secretases, specifically the beta, and gamma, secretases. Certain mutations in the APP gene are associated with familial forms of AD, as are mutations in the genes encoding proteins forming the secretase enzymes, in line with the hypothesis that Abeta, accumulation is central to the AD disease process. Our antibody recognizes amino acids 1-16 of the Abeta, peptide and works well on western blots, on formalin fixed sections and as a capture reagent in ELISA. It was originally developed in the Mayo Clinic in Jacksonville in the laboratory of Dr. Todd Golde.

Pathways: Inflammasome