TIE1 Antikörper

Produktnummer ABIN155171

Produktdetails anti-TIE1 Antikörper

Target: TIE1 (tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TIE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), Flow Cytometry (FACS)

Spezifität: This antibody will detect native TIE-1 in ELISA experiments and on the surface of different cell types.

Aufreinigung: Protein G chromatography

Immunogen: Recombinant human soluble TIE-1 protein

Klon: 6F12

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1-15 μg/mL. Western blot: 1-2 μg/mL. FACS. Cell sorting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in sterile water to a concentration of 1.0 mg/mL.

Buffer: PBS, pH 7.4 without preservatives or stabilizers

Konservierungsmittel: Without preservative

Handhabung: This product is photosensitive and should be protected from light

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted Prior to and After reconstitution at 2-8 °C. DO NOT FREEZE!

Details zu TIE1

Target: TIE1 (tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1))

Andere Bezeichnung: TIE1 (TIE1 Produkte)

Synonyme: JTK14 antikoerper, TIE antikoerper, D430008P04Rik antikoerper, tie-1 antikoerper, tyrosine kinase with immunoglobulin like and EGF like domains 1 antikoerper, tyrosine kinase with immunoglobulin-like and EGF-like domains 1 antikoerper, tyrosine-protein kinase receptor Tie-1 antikoerper, endothelium-specific receptor tyrosine kinase 1 antikoerper, TIE1 antikoerper, Tie1 antikoerper, CpipJ_CPIJ018933 antikoerper, tie1 antikoerper

Hintergrund: TIE1/TIE (tyrosine kinase with Ig and EGF homology domains 1) and TIE2/Tek define a new class of the receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin like domains flanking three epidermal growth factor (EFG) like domains followed by three fibronectin type III like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. Human TIE1 cDNA encodes a 1138 amino acid residue precursor protein with a putative signal peptide, an extracellular domain, and a cytoplasmic domain. Human TIE1/Fc, a disulfide linked homodimeric protein, has a calculated molecular mass of approximately 107 kDa. Due to glycosylation, the protein migrates to approximately 160 kDa in SDS PAGE under reducing conditions. TIE1 and TIE2, expressed primarily on endothelial and hematopoietic progenitor cells, play important roles in angiogenesis, vasculogenesis, and hematopoiesis. In developing vascular endothelial cells, TIE1 and TIE2 are specifically expressed. Two ligands that bind TIE have been identified, angiopoietin 1 and angiopoietin 2. Based on gene targeting studies, the in vivo functions of TIE1 are related to endothelial cell differentiation. The receptor tyrosine kinase TIE also plays a role in the survival and integrity of the endothelium.Synonyms: TIE, Tie-1, Tyrosine-protein kinase receptor Tie-1

Gen-ID: 7075

NCBI Accession: NP_005415

UniProt: P35590

Pathways: RTK Signalweg