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MAF Antikörper (N-Term)

MAF Reaktivität: Maus WB Wirt: Kaninchen Polyclonal RB40270 unconjugated
Produktnummer ABIN1539064
  • Target Alle MAF Antikörper anzeigen
    MAF (V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF))
    Bindungsspezifität
    • 15
    • 14
    • 8
    • 8
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 14-42, N-Term
    Reaktivität
    • 53
    • 49
    • 17
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Maus
    Wirt
    • 66
    • 3
    Kaninchen
    Klonalität
    • 64
    • 5
    Polyklonal
    Konjugat
    • 33
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MAF Antikörper ist unkonjugiert
    Applikation
    • 41
    • 29
    • 13
    • 13
    • 9
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Homologie
    B, C, H, Rat
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This Mouse Maf antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of mouse Maf.
    Klon
    RB40270
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Mouse Maf Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
    Haltbarkeit
    6 months
  • Target
    MAF (V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF))
    Andere Bezeichnung
    Maf (MAF Produkte)
    Synonyme
    MAF antikoerper, DKFZp459D1731 antikoerper, 2810401A20Rik antikoerper, A230108G15Rik antikoerper, AW047063 antikoerper, c-maf antikoerper, CCA4 antikoerper, c-MAF antikoerper, Maf2 antikoerper, cMaf antikoerper, Z-cmaf antikoerper, c-Maf antikoerper, fl13d12 antikoerper, wu:fl13d12 antikoerper, C-Maf antikoerper, MAF bZIP transcription factor antikoerper, v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) antikoerper, avian musculoaponeurotic fibrosarcoma oncogene homolog antikoerper, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a) antikoerper, MAF antikoerper, Maf antikoerper, mafa antikoerper
    Hintergrund
    Maf acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters (By similarity). Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha-and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf-responsive element binding.
    Molekulargewicht
    38435
    Gen-ID
    17132
    NCBI Accession
    NP_001020748
    UniProt
    P54843
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