Lamin A/C Antikörper (AA 401-427)

Produktnummer ABIN1538393

Der Kaninchen Polyklonal Anti-Lamin A/C-Antikörper wurde für WB validiert. Er ist geeignet, Lamin A/C in Proben von Human zu detektieren.

Kurzübersicht für Lamin A/C Antikörper (AA 401-427) (ABIN1538393)

Target: Lamin A/C (LMNA)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Lamin A/C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB21443

Produktdetails anti-Lamin A/C Antikörper

Bindungsspezifität: AA 401-427

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This LMNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-427 amino acids from the Central region of human LMNA.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: LMNA Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu Lamin A/C

Target: Lamin A/C (LMNA)

Andere Bezeichnung: LMNA

Hintergrund: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Molekulargewicht: 74139

Gen-ID: 4000

NCBI Accession: NP_001244303, NP_005563, NP_733821, NP_733822

UniProt: P02545

Pathways: Apoptose, Caspase Kaskade in der Apoptose, ER-Nucleus Signaling, Protein targeting to Nucleus