STK4 Antikörper (C-Term)

Produktnummer ABIN1537341

Der Kaninchen Polyklonal anti-STK4 Antikörper (Klon RB37147) (ABIN1537341) detektiert spezifisch STK4 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für STK4 Antikörper (C-Term) (ABIN1537341)

Target: STK4 (serine/threonine Kinase 4 (STK4))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STK4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB37147

Produktdetails anti-STK4 Antikörper

Bindungsspezifität: AA 443-470, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Stk4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 443-470 amino acids from the C-terminal region of mouse Stk4.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Mouse Stk4 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu STK4

Target: STK4 (serine/threonine Kinase 4 (STK4))

Andere Bezeichnung: Stk4

Hintergrund: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.

Molekulargewicht: 55541

Gen-ID: 58231

NCBI Accession: NP_067395

UniProt: Q9JI11

Pathways: Tube Formation