Akirin 1 Antikörper (C-Term)

Produktnummer ABIN1536697

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Akirin 1 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Akirin 1 Antikörper (C-Term) (ABIN1536697)

Target: Akirin 1 (AKIRIN1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Akirin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB25247

Produktdetails anti-Akirin 1 Antikörper

Bindungsspezifität: AA 131-158, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This AKIR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-158 amino acids from the C-terminal region of human AKIR1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: AKIR1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu Akirin 1

Target: Akirin 1 (AKIRIN1)

Andere Bezeichnung: AKIR1

Hintergrund: The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways. AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.

Molekulargewicht: 21867

Gen-ID: 79647

NCBI Accession: NP_001129747, NP_078871

UniProt: Q9H9L7