Akirin 1 Antikörper

Produktnummer ABIN1386924

Produktdetails anti-Akirin 1 Antikörper

Target: Akirin 1 (AKIRIN1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Akirin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AKIRIN1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu Akirin 1

Target: Akirin 1 (AKIRIN1)

Andere Bezeichnung: AKIRIN1 (AKIRIN1 Produkte)

Synonyme: C1orf108 antikoerper, RP11-781D11.2 antikoerper, STRF2 antikoerper, 6330407G11Rik antikoerper, wu:fa96c11 antikoerper, wu:fc08a11 antikoerper, zgc:64050 antikoerper, AKIRIN1 antikoerper, strf2 antikoerper, akirin 1 antikoerper, akirin 1 S homeolog antikoerper, akirin-1 pseudogene antikoerper, AKIRIN1 antikoerper, Akirin1 antikoerper, akirin1 antikoerper, akirin1.S antikoerper, LOC100316864 antikoerper, LOC100356339 antikoerper

Hintergrund:

Synonyms: AKIRIN 1, C1orf108, FLJ12666, OTTHUMP00000008669, RP11-781D11.2, STRF2, AKIR1_HUMAN.

Background: AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways.