MASP1 Antikörper (Cleaved-Arg448)

Produktnummer ABIN1536127

Der Kaninchen Polyklonal anti-MASP1 Antikörper wird verwendet zum Nachweis von MASP1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und ELISA.

Kurzübersicht für MASP1 Antikörper (Cleaved-Arg448) (ABIN1536127)

Target: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MASP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-MASP1 Antikörper

Bindungsspezifität: AA 399-448, Cleaved-Arg448

Verwendungszweck: Cleaved-MASP-1 HC (R448) Antibody

Spezifität: Cleaved-MASP-1 HC (R448) Polyclonal Antibody detects endogenous levels of fragment of activated MASP-1 HC protein resulting from cleavage adjacent to R448.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human MASP1. AA range:399-448

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu MASP1

Target: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Andere Bezeichnung: MASP1

Hintergrund:

Synonyms: MASP1, CRARF, CRARF1, PRSS5, Mannan-binding lectin serine protease 1, Complement factor MASP-3, Complement-activating component of Ra-reactive factor, Mannose-binding lectin-associated serine protease 1, MASP-1, Mannose-binding protein-asso

Background: mannan binding lectin serine peptidase 1(MASP1) Homo sapiens This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[p

Gene Name: MASP1

Protein Name: Mannan-binding lectin serine protease 1

Molekulargewicht: 47 kDa

Gen-ID: 5648

OMIM: 600521

UniProt: P48740

Pathways: Komplementsystem