Caspase 3 Antikörper (Cleaved-Asp175)

Produktnummer ABIN1536081

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Caspase 3 in WB, IHC, ELISA und IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Caspase 3 Antikörper (Cleaved-Asp175) (ABIN1536081)

Target: Caspase 3 (CASP3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-Caspase 3 Antikörper

Bindungsspezifität: AA 157-206, Cleaved-Asp175

Verwendungszweck: Cleaved-Caspase-3 p12 (D175) Antibody

Spezifität: Cleaved-Caspase-3 p12 (D175) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-3 p12 protein resulting from cleavage adjacent to D175.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Caspase 3. AA range:157-206

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000, IHC 1:50-300, IF 1:50-300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu Caspase 3

Target: Caspase 3 (CASP3)

Andere Bezeichnung: Caspase 3

Hintergrund:

Synonyms: CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1

Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008],

Gene Name: CASP3

Protein Name: Caspase3

Molekulargewicht: 20 and 35 kDa

Gen-ID: 836

OMIM: 600636

UniProt: P42574

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation