ARHGEF3 Antikörper (AA 456-505)

Produktnummer ABIN1535299

Der Kaninchen Polyklonal anti-ARHGEF3 Antikörper wird verwendet zum Nachweis von ARHGEF3 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC, ELISA und IF.

Kurzübersicht für ARHGEF3 Antikörper (AA 456-505) (ABIN1535299)

Target: ARHGEF3 (rho Guanine Nucleotide Exchange Factor (GEF) 3 (ARHGEF3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARHGEF3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-ARHGEF3 Antikörper

Bindungsspezifität: AA 456-505

Verwendungszweck: XPLN Antibody

Spezifität: XPLN Polyclonal Antibody detects endogenous levels of XPLN protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human ARHGEF3. AA range:456-505

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000.IHC:1:50-300 ELISA: 1:20000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu ARHGEF3

Target: ARHGEF3 (rho Guanine Nucleotide Exchange Factor (GEF) 3 (ARHGEF3))

Andere Bezeichnung: ARHGEF3

Hintergrund:

Synonyms: ARHGEF3, Rho guanine nucleotide exchange factor 3, Exchange factor found in platelets and leukemic and neuronal tissues, XPLN

Background: Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP.This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Gene Name: ARHGEF3

Protein Name: Rho guanine nucleotide exchange factor 3

Molekulargewicht: 59 kDa

Gen-ID: 50650

UniProt: Q9NR81

Pathways: Neurotrophin Signalübertragung